LNP Kits to Visualize Uptake and Localization
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Evaluate delivery of eGFP, FLuc or mCherry mRNA for in vitro transfection.
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Evaluate LNP uptake with conveniently labeled lipophilic dyes (e.g. DiR, DiI, and BODIPY)
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Ask us for custom synthesis of your RNA cargo!
*LNP uptake data in collaboration with Cayman Chemicals
Accelerate your LNP Formulation Development
using EZNano Kits
In Vitro Evaluation
Quickly screen LNP formulations for cellular uptake and viability.
Scale-up and Optimization
Leverage insights and our expertise to refine LNP formulations for larger studies
In Vivo Biodistribution
Understand the localization of your LNP-API complex
EZNano LNPs in Literature
Wenhan Wang, Kangfu Chen, Zongjie Wang
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Northwestern University​
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This study shows that blocking the kinase PIK3CA can substantially improve how well lipid nanoparticles (LNPs) deliver siRNA. Using a genome‑wide CRISPR screen, the authors identify PIK3CA as a key, druggable regulator of LNP uptake, then demonstrate that co‑treating cells and mice with the clinical inhibitor BAY1082439 boosts LNP internalization by up to fivefold, enhances siRNA‑mediated gene silencing, and improves outcomes in both tumor and inflammatory disease models. Overall, PIK3CA inhibition emerges as a straightforward strategy to increase the efficacy of LNP‑based siRNA therapies.
